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Su Zheng is an Associate Research Fellow, Assistant to the Director, Research Group Leader, Innovation Officer in the Department of Orthopaedics, Executive Director of the Orthopedic Laboratory, Postdoctoral Supervisor. His research focuses primarily on bone infections and immunology. He obtained his PhD from the University of Science and Technology of China in 2019 under the supervision of Professor Tian Xingyou. During his PhD, he spent a year as a visiting scholar at Queen's University Belfast in the UK. He completed his postdoctoral training under the supervision of Director Zhu Chen and Professor Wang Yucai, after which he was promoted to Associate Research Fellow at the First Affiliated Hospital of the University of Science and Technology of China in 2022. With over 12 years of research experience, his work focuses on four key areas: 1) the prevention and treatment of periprosthetic bone infections, 2) elucidating bacterial biofilm structures, 3) developing biofilm-based organ-on-a-chip systems, and 4) creating portable infection detection devices. The laboratory is interested in advancing research aimed at elucidating these complex interactions with a view to refining treatment strategies for managing infections and immune-mediated diseases and promoting public health security. This includes analysing the structural characteristics of bacterial biofilms, understanding pathogen-induced immune mechanisms, optimising immunomodulatory adjuvants, addressing chronic infections, advancing personalised medicine, strengthening public health strategies, developing antimicrobial test strips and using AI for disease prediction and treatment.
As the first author, he has published fifteen SCI papers in renowned international academic journals such as Science Advances, Drug Resistance Updates, Nature Communications and Coordination Chemistry Reviews. As the corresponding author, he has published fourteen SCI papers in renowned international academic journals such as Nature Communications, Coordination Chemistry Reviews, Cell Reports Physical Science, ACS Nano, Biomaterials (two papers), Research, Advanced Functional Materials (two papers), Bioactive Materials (two papers), Cell Biomaterials, Nano Today and Journal of Visualized Experiments. He serves as a national committee member of the Basic Research Group of the Orthopaedic Surgeons Branch of the Chinese Medical Doctors Association; a national committee member of the Geriatric Bone and Joint Diseases Branch of the Chinese Geriatric Health Care Medical Research Association; a committee member of the Bone and Joint Branch of the Chinese Geriatric Health Care Association; and deputy head of the Basic Research Group of the Orthopaedic Surgery Branch of the Anhui Medical Association. He has been selected as a reviewer for Science Bulletin (Q1, General), Journal of Orthopaedic Translation (Q1, Medicine), Infectious Medicine and Burns & Trauma (Q1, Medicine), and has reviewed manuscripts for SCI journals including Nature Communications, eBioMedicine, Bioactive Materials, International Journal of Biological Macromolecules, Advanced Materials, ACS Nano, ACS Applied & Interface Materials, Advanced Science, Composites Part B and Carbohydrate Polymers.
He has led projects including the General Programme and the Youth Programme of the National Natural Science Foundation of China, the General Programme of the China Postdoctoral Science Foundation, a Key Research and Development Project of the Anhui Provincial Department of Education, an Anhui Provincial Health and Wellness Research Project, the New Medicine Cultivation Project at the University of Science and Technology of China, and the Cultivation Project of the Institute of Pioneering Medicine and Frontier Technologies at the Hefei Comprehensive National Science Centre. He has also participated in the Key Research and Development Programme of the Ministry of Science and Technology, the General Projects of the National Natural Science Foundation of China, the Anhui Provincial Key Research and Development Programme, the Anhui Provincial Key Programme for Clinical Translation, the Key Project for New Medicine at the University of Science and Technology of China, and the Pioneer Programme of the Institute of Health and Wellness. Recognised as one of the first cohorts of high-level talent recruited by provincial public healthcare institutions in Anhui Province; recognised as Hefei Municipal Leading Talent; nominated for the Top Ten Annual Scientific and Technological Advances by the School of Life Sciences and Medicine at the University of Science and Technology of China; recipient of the First Class 'Mozi Outstanding Young Scholar Special Allowance' from the University of Science and Technology of China; recipient of the Second Prize of the Anhui Provincial Medical Science and Technology Award (third out of seven); member of the Anhui Provincial Outstanding Postgraduate Supervisor Team (fifth out of five); Outstanding Scientific Research and Innovation Team of the Anhui Provincial Department of Education (fourth out of sixteen); and First Prize in the Anhui Provincial Science and Technology Progress Award (2nd out of 10), amongst others.
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Email: suz924@ustc.edu.cn
Published articles:
【#】. Su Zheng#; Kong Lingtong#; Dai Yong#; Tang Jin*; Mei Jiawei; Qian Zhengzheng; Ma Yuanyuan; Li Qianming; Ju Shenghong; Wang Jiaxing*; Fan Wenpei*; Zhu Chen*, Bioresponsive nano-antibacterials for H2S-sensitized hyperthermia and immunomodulation against refractory implant-related infections. Science Advances 2022, 8 (14), eabn1701.
【#】. Su Zheng#; Kong Lingtong#; Mei Jiawei; Li Qianming; Qian Zhengzheng; Ma Yuanyuan; Chen Yue; Ju Shenghong; Wang Jiaxing*; Jia Weitao*; Zhu Chen*; Fan Wenpei*, Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation. Drug Resistance Updates 2023, 67, 100917.
【#】. Su Zheng#*; Xu Dongdong#; Hu Xianli#; Zhu Wanbo*; Kong Lingtong; Qian Zhengzheng; Mei Jiawei; Ma Ruixiang; Shang Xifu; Fan Wenpei*; Zhu Chen*, Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections. Nature Communications 2024, 15 (1), 8058.
【#】. Mei Jiawei#; Liu Quan#; Hu Xianli#; Wang Wenzhi#; Ma Ruixiang#; Zhu Wanbo*; Zhu Chen*; Su Zheng*, Animal Model of Implant-Associated Infections in Mice. Journal of Visualized Experiments 2025, doi:10.3791/68041 (220), e68041.
【#】. Su Zheng#*; Hu Xianli#; Sun Jiaxuan#; Zhang Tao, Zhang Rui; Lv Jiahang; Sun Haibo; Ma Ruixiang; Liu Yingsheng; Shen Xianyue; Liu Mengxing; Li Zhenyu; Bai Jiaxiang*; Zhang Xianzuo*; Zhu Chen*, Cross-disciplinary translation of paper-based sensors for bacterial detection. Coordination Chemistry Reviews 2026, 567, 218322.
【#】. Hu Xianli#; Ma Ruixiang#; Zhang Peng#; Dong Jiale; Sun Jiaxuan; Wang Wenzhi; Liu Quan; Kong Lingtong; Zhang Xudong; Wang Zhengxi; Mei Jiawei; Shang Xifu; Zhu Wanbo*; Su Zheng*; Zhu Chen*, Biomimetic Metal–Organic Framework Combats Biofilm-Associated Infections via Hyperthermia-Enhanced Bacterial Metabolic Interference and Autophagy-Promoted Adaptive Immunity. Advanced Functional Materials 2024, 34, 2310509.
【#】. Wang Zhengxi#; Zhang Xudong#; Liu Quan#; Hu Xianli; Mei Jiawei; Zhou Jun; Zhang Xianzuo; Xu Dongdong*; Zhu Wanbo*; Su Zheng*; Zhu Chen*, Balancing bioresponsive biofilm eradication and guided tissue repair via pro-efferocytosis and bi-directional pyroptosis regulation during implant surgery. ACS Nano 2024, 18(20), 13196-13213
【#】. Zhang Peng#; Hu Xianli#; Liu Quan#; Wang Wenzhi; Sun Jiaxuan; Ma Ruixiang; Mei Jiawei; Zhang Xianzuo; Zhu Wanbo*; Su Zheng*; Zhu Chen*, An enzymatic and metal-organic framework system to prevent biofilm infections. Cell Reports Physical Science 2025, 6, 102468.
【#】. Kong Lingtong#; Hu Xianli#; Xia Demeng#; Wu Jianghong*; Zhao Yangpeng; Guo Hua; Zhang Song; Qin Chun; Wang Yanjun; Li Lei; Su Zheng*; Zhu Chen*; Xu Shuogui*, Janus PEGylated CuS-engineered Lactobacillus casei combats biofilm infections via metabolic interference and innate immunomodulation. Biomaterials 2025, 317, 123060.
【#】. Yang Ning#; Wu Ting#; Li Meng#, Hu Xianli; Zhang Xianzuo; Ma Ruixiang; Li Qianming; Jiang Wei; Su Zheng*; Yang Rong*; Zhu Chen*, Silver-Quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming. Bioactive Materials 2025, 43, 48-66.
【#】. Liu Quan#; Mei Jiawei#; Wang Zhengxi#; Zhang Xudong; Hu Xianli; Xu Dongdong; Zhou Jun; Li Qianming; Ma Ruixiang; Zhang Xianzuo; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Nano-Fat Actuated Lipometabolic Reprogramming of Macrophages for Intracellular Infections in Biofilm Microenvironment. Advanced Functional Materials 2024, 2405852.
【#】. Xu Dongdong#; Hu Jun#; Mei Jiawei#; Zhou Jun; Wang Zhengxi; Zhang Xudong; Liu Quan; Su Zheng*; Zhu Wanbo*; Liu Hongjian*; Zhu Chen*, Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections. Bioactive Materials 2024, 35, 82-98.
【#】. Dong Jiale#; Zhou Wei#; Hu Xianli#; Bai Jiaxiang*; Zhang Siming; Zhang Xianzuo; Yu Lei; Yang Peng; Kong Lingtong; Liu Mingkai; Shang Xifu; Su Zheng*; Geng Dechun*; Zhu Chen*, Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation. Biomaterials 2024, 307, 122515.
【#】. Zhu Wanbo#; Mei Jiawei#; Xu Dongdong#; Wang Jiaxing*; Zhou Jun; Hu Xianli; Liu Quan; Su Zheng*; Wang Qiaojie; Zhu Chen*; Zhang Xianlong*, Therapeutic in situ nano-vaccine for combating medical implant-related biofilm infection. Cell Biomaterials 2025, https://doi.org/10.1016/j.celbio.2025.100131, 100131.
【#】. Li Zhenyu; Jia Guoqiang; Su Zheng*; Zhu Chen*, Nanozyme-Based Strategies against Bone Infection. Research 2025, 8, 0605.
【#】. Li Qianming#; Liu Quan#; Wang Zhengxi; Zhang Xianzuo; Ma Ruixiang; Hu Xianli; Mei Jiawei*; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Biofilm Homeostasis Interference Therapy via 1O2-Sensitized Hyperthermia and Immune Microenvironment Re-Rousing for Biofilm-Associated Infections Elimination. Small 2023, 19, 2300592.
【#】. Zhang Xudong#; Wang Zhengxi#; Liu Quan#; Hu Xianli; Mei Jiawei; Xu Dongdong; Zhou Jun; Zhang Xianzuo; Li Qianming; Chen Hua; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Targeted modulation and enhancement of macrophages via sonodynamic therapy-driven cupferroptosis-like stress for implant-associated biofilm infections. Nano Today 2024, 54, 102092.
【#】. Zhang Siming#; Ge Gaoran#; Li Wenhao#; Dong Jiale; Hu Xianli; Qin Yi; Zhang Peng; Bai Jiaxiang; Zhang Weiwei*; Su Zheng*; Geng Dechun*; Zhu Chen*, Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties. Materials Today Bio 2025, 32, 101906.
【#】. Yang Jiazhao; Zhang Xudong; Lu Baoliang; Mei Jiawei; Xu Lei; Zhang Xianzuo; Su Zheng; Xu Wei; Fang Shiyuan; Zhu Chen; Xu Dongdong; Zhu Wanbo, Inflammation-Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual-Homeostatic Modulation Strategy. Advanced Science 2023, 10, 2302905.
【#】. Mei Jiawei; Xu Dongdong; Wang Lingtian; Kong Lingtong; Liu Quan; Li Qianming; Zhang Xianzuo; Su Zheng; Hu Xianli; Zhu Wanbo; Ye Ming; Wang Jiaxing; Zhu Chen, Biofilm Microenvironment-Responsive Self-Assembly Nanoreactors for All-stage Biofilm Associated Infection through Bacterial Cuproptosis-like Death and Macrophage Re-rousing. Advanced Materials 2023, 35, 2303432.
【#】. Zhu Wanbo; Mei Jiawei; Zhang Xianzuo; Zhou Jun; Xu Dongdong; Su Zheng; Fang Shiyuan; Wang Jiaxing; Zhang Xianlong; Zhu Chen, Photothermal Nanozyme-based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron-actuated Janus Ion Therapy. Advanced Materials 2022, 34, 2207961.
【#】. Ma Yuanyuan; Su Zheng; Zhou Liming; He Liangcan; Hou Zhenyu; Zou Jianhua; Cai Yu; Chang Di; Xie Jinbing; Zhu Chen; Fan Wenpei; Chen Xiaoyuan; Ju Shenghong, Biodegradable Metal-Organic Framework-Gated Organosilica for Tumor Microenvironment-Unlocked Glutathione Depletion-Enhanced Synergistic Therapy. Advanced Materials 2022, 32, 2107560.
【#】. Ma Ruixiang; Hu Xianli; Zhang Xianzuo; Wang Wenzhi; Sun Jiaxuan; Su Zheng*; Zhu Chen*, Strategies to prevent, curb and eliminate biofilm formation based on the characteristics of various periods in one biofilm life cycle. Frontiers in Cellular and Infection Microbiology 2022, 12, 1003033.
【#】. Ye Xianzhu; Wang Hua; Zheng Kang; Wu Zhaofeng; Zhou Haifeng; Tian Konghu; Su Zheng; Tian Xingyou, The interface designing and reinforced features of wood fiber/polypropylene composites: Wood fiber adopting nano-zinc-oxide-coating via ion assembly. Composites Science and Technology 2016, 124, 1-9.
【#】. Su Zheng; Sun Daye; Zhang Li; He Miaomiao; Jiang Yulin; Millar Bronagh; Douglas Paula; Mariotti Davide; Maguire Paul; Sun Dan*, Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions. Materials 2021, 14 (9), 2351.
【#】. Su Zheng; Wang Hua*; Tian Xingyou*, Time and space dependence of large-scale synthesis of colloidal particle with special morphology and tuneable polymer film architecture. International Journal of Adhesion and Adhesives 2019, 95, 102380.
【#】. Su Zheng; Wang Hua*; He Jing; Guo Yulan; Qu Qiqi; Tian Xingyou*, Fabrication of Thermal Conductivity Enhanced Polymer Composites by Constructing an Oriented Three-Dimensional Staggered Interconnected Network of Boron Nitride Platelets and Carbon Nanotubes. ACS Applied Materials & Interfaces 2018, 10 (42), 36342-36351.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Huang Weiqi; Xiao Chao; Guo Yulan; He Jing; Tian Xingyou*, The combination of π-π interaction and covalent bonding can synergistically strengthen the flexible electrical insulating nanocomposites with well adhesive properties and thermal conductivity. Composites Science and Technology 2018, 155, 1-10.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Huang Weiqi; Guo Yulan; He Jing; Tian Xingyou*, Multifunctional anisotropic flexible cycloaliphatic epoxy resin nanocomposites reinforced by aligned graphite flake with non-covalent biomimetic functionalization. Composites Part A: Applied Science and Manufacturing 2018, 109, 472-480.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; He Jing; Guo Yulan; Tian Xingyou*, Anisotropic thermally conductive flexible polymer composites filled with hexagonal born nitride (h-BN) platelets and ammine carbon nanotubes (CNT-NH2): Effects of the filler distribution and orientation. Composites Part A: Applied Science and Manufacturing 2018, 109, 402-412.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; He Jing; Guo Yulan; Tian Xingyou*, Synergistic enhancement of anisotropic thermal transport flexible polymer composites filled with multi-layer graphene (mG) and mussel-inspiring modified hexagonal boron nitride (h-BN). Composites Part A: Applied Science and Manufacturing 2018, 111, 12-22.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; Xiao Chao; Tian Xingyou*, Enhanced thermal conductivity of functionalized-graphene/boron nitride flexible laminated composite adhesive via a facile latex approach. Composites Part A: Applied Science and Manufacturing 2017, 99, 166-175.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; Guo Yulan; He Jing; Tian Xingyou*, Non-covalent poly (2-ethylhexyl acrylate) (P2EHA)/functionalized graphene/h-boron nitride flexible composites with enhanced adhesive and thermal conductivity by a facilitated latex approach. Composites Part A: Applied Science and Manufacturing 2017, 99, 176-185.
【#】. Su Zheng; Wang Hua*; Xu Fei; Tian Konghu; Wu Jingwei; Tian Xingyou*, Tunable composite architecture and homogeneous dispersion of charged SiO2 in polymer matrix assisted by poly(2-ethylhexyl acrylate) (P2EHA) latex prepared by self-assembly through electrostatic interactions. Rsc Advances 2016, 6 (7), 5621-5630.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Xu Fei; Huang Weiqi; Tian Xingyou*, Simultaneous reduction and surface functionalization of graphene oxide with wrinkled structure by diethylenetriamine (DETA) and their reinforcing effects in the flexible poly(2-ethylhexyl acrylate) (P2EHA) films. Composites Part A: Applied Science and Manufacturing 2016, 84, 64-75.
